Trending...
- Heritage at South Brunswick Introduces New Ferndale Floorplan: The Largest Single-Family Home Design in the Community - 130
- Avenue Dental Care North Spokane Offers Free Emergency Care to Firefighters
- City of Spokane Staff on Hand at Disaster Assistance Center
SEATTLE, May 13, 2024 ~ Seattle, WA- With the number of pediatric inflammatory bowel disease (IBD) diagnoses increasing globally, a clinical trial in Seattle is aiming to revolutionize treatment approaches through deep molecular profiling. The Seattle STRIDE study, a collaboration between Seattle Children's Research Institute and the Allen Institute for Immunology, has begun recruiting volunteers for its three-year study.
The trial plans to enroll 200 participants and utilize genomic tools to analyze tissue samples from routine tests. These single-cell analysis methods will provide a detailed understanding of how the immune system behaves in patients with IBD and how it responds to specific drug treatments over time.
According to Dr. Betty Zheng, an assistant professor of pediatrics at Seattle Children's and the principal investigator of the study, this deep immune profiling could offer an unprecedented view of the disease and potentially lead to new and improved treatments.
"IBD is a complex disease and we still have a limited understanding of its molecular mechanisms," said Dr. Zheng. "By partnering with the Allen Institute, we hope to gain a detailed view of these mechanisms in order to find better ways of treating our patients."
More on Washingtoner
The exact causes and progression of IBD, a chronic inflammatory condition affecting the digestive tract, have remained elusive. It is believed that a combination of genetic factors, immune dysregulation, and environmental or dietary factors may play a role.
In children, IBD can be more aggressive and difficult to treat compared to adults. Approximately 30% of pediatric IBD patients do not respond to initial treatments and nearly half will eventually become resistant to their current treatments. This can lead to serious consequences such as impaired growth, mental health issues, and missed educational and social activities.
Dr. Zheng believes that a deeper understanding of the molecular workings of the disease could lead to personalized treatment strategies instead of relying on one-size-fits-all approaches.
"Some children respond well to first-line therapies while others require multiple treatments or do not respond at all," she explained. "This is a major challenge in the clinic."
In addition to potentially improving treatment options, a deep dive into the molecular mechanisms of IBD could also uncover new pathways of inflammation that could be targeted for the development of new drugs.
More on Washingtoner
Dr. Adam Savage, an assistant investigator at the Allen Institute for Immunology, emphasized the importance of exploring these unknown pathways.
"There is a universe of information that is not being seen," he said.
To uncover this information, Dr. Savage and his team will utilize advanced technologies developed at the Allen Institute for Immunology to identify and pinpoint immune cells and molecules within tissue samples collected during routine hospital visits. By analyzing these samples over time, they hope to gain insight into how the disease progresses and how patients respond to treatment.
While the study may involve complex data and advanced technologies, Dr. Savage reminds us that the ultimate goal is to improve the lives of patients.
"We may look at data on computers or work in labs, but when we see the patients we are trying to help, it serves as a powerful reminder of why we do what we do - to have a real impact on patients' lives," he said.
Families interested in participating in the Seattle STRIDE study can find more information on their website. The study offers hope for improved treatments and better outcomes for children with IBD.
The trial plans to enroll 200 participants and utilize genomic tools to analyze tissue samples from routine tests. These single-cell analysis methods will provide a detailed understanding of how the immune system behaves in patients with IBD and how it responds to specific drug treatments over time.
According to Dr. Betty Zheng, an assistant professor of pediatrics at Seattle Children's and the principal investigator of the study, this deep immune profiling could offer an unprecedented view of the disease and potentially lead to new and improved treatments.
"IBD is a complex disease and we still have a limited understanding of its molecular mechanisms," said Dr. Zheng. "By partnering with the Allen Institute, we hope to gain a detailed view of these mechanisms in order to find better ways of treating our patients."
More on Washingtoner
- Spokane: Notice of Intent to Make a Section 4(f) De Minimis Impact Determination
- Spokane Complex Fire Parks & Recreation update 08-12-26
- Ignazio Arces Wins Stevie® Award for Maverick of the Year at the 2026 International Business Awards
- Tickeron Highlights AI Trading Agent Performance Across Multiple Market Sectors
- Stop Bleeding Cash on Mediocre Talent. Build a Powerhouse Remote Team Instead
The exact causes and progression of IBD, a chronic inflammatory condition affecting the digestive tract, have remained elusive. It is believed that a combination of genetic factors, immune dysregulation, and environmental or dietary factors may play a role.
In children, IBD can be more aggressive and difficult to treat compared to adults. Approximately 30% of pediatric IBD patients do not respond to initial treatments and nearly half will eventually become resistant to their current treatments. This can lead to serious consequences such as impaired growth, mental health issues, and missed educational and social activities.
Dr. Zheng believes that a deeper understanding of the molecular workings of the disease could lead to personalized treatment strategies instead of relying on one-size-fits-all approaches.
"Some children respond well to first-line therapies while others require multiple treatments or do not respond at all," she explained. "This is a major challenge in the clinic."
In addition to potentially improving treatment options, a deep dive into the molecular mechanisms of IBD could also uncover new pathways of inflammation that could be targeted for the development of new drugs.
More on Washingtoner
- Crownlight Strategies® Announces Federal Trademark Registration
- Spokane: PPE Available to Those Returning Home After New Evacuation Downgrades
- Spokane Police Respond to a Vehicle vs. Pedestrian
- New Book Calls 'Sense of Belonging' the Missing Link in Student Success
- Tacoma City Council Set to Join Pierce County's Efforts to Launch Unified Regional Approach to Reduce Homelessness
Dr. Adam Savage, an assistant investigator at the Allen Institute for Immunology, emphasized the importance of exploring these unknown pathways.
"There is a universe of information that is not being seen," he said.
To uncover this information, Dr. Savage and his team will utilize advanced technologies developed at the Allen Institute for Immunology to identify and pinpoint immune cells and molecules within tissue samples collected during routine hospital visits. By analyzing these samples over time, they hope to gain insight into how the disease progresses and how patients respond to treatment.
While the study may involve complex data and advanced technologies, Dr. Savage reminds us that the ultimate goal is to improve the lives of patients.
"We may look at data on computers or work in labs, but when we see the patients we are trying to help, it serves as a powerful reminder of why we do what we do - to have a real impact on patients' lives," he said.
Families interested in participating in the Seattle STRIDE study can find more information on their website. The study offers hope for improved treatments and better outcomes for children with IBD.
0 Comments
Latest on Washingtoner
- Gateway Center Arena Announces Duane Curry as General Manger
- Spokane Police Respond to Overnight Shooting in Garland District
- XRPPower Expands Platform Security With Enhanced Brand Protection and Official Verification Standards
- Spokane-Area VFW Posts Open Their Doors to Wildfire Evacuees
- QuickBooks Online Advanced: Features, Benefits Guide
- Cuvo Health, the #1 White Label Telehealth Platform, Surpasses 300 Exclusive Providers Serving All 50 States
- Spokane: City To Provide Extra Garbage Collection for Downgraded Evacuation Zones
- Spokane: City offers guidance on safely returning home after fires
- Qustone Brings Leadership as Infrastructure to the Commercial Space Ecosystem
- Inappropriate Jazz - It's a Musical!
- Spokane: City Testing Shows Water Quality is Safe
- RAS AP Consulting Expands Managed AP Governance™ Ecosystem, Launches Trademark Process, and Secures IFOL Speaker Invitation
- UK Financial Ltd Makes History: Chainlink CRE Circulating Supply Verification Goes Live Across Its Complete Ecosystem Of Nine Exchange-Traded Tokens
- International Rights Groups Raise Alarm Over Freedom of Religion and Expression in South Korea
- WDTA Hosts Landmark DWC Seattle AI Summit in Bellevue, Bridging AI Governance and Innovation
- City of Spokane Staff on Hand at Disaster Assistance Center
- Tacoma: Homicide Investigation – 2100 block of N 30th St
- The City's Most Elegant Open-Air Dinner Party Returns September 12, 2026
- Spokane: Incorrect Info Regarding Downgraded Evacuation Status on Popular App
- FDA Clears Major Regulatory Hurdle as Preservative-Free Ketamine Program Moves Within Reach of Commercialization: NRx Pharmaceuticals: (NAS DAQ: NRXP)