Trending...
- Wohler announces three SRT monitoring enhancements for its iVAM2-MPEG monitor and the addition of front panel PID selection of A/V/subtitle streams
- Safe Health Zones: A Global Breakthrough to Protect Night-Shift Workers from Preventable Harm
- Curated Domain Name Marketplace
SEATTLE--(BUSINESS WIRE)--NanoString Technologies, Inc. (NASDAQ: NSTG), a leading provider of life science tools for discovery and translational research, today announced that two peer-reviewed publications using the GeoMx® Digital Spatial Profiler have been published in Nature and Nature Communications. These papers describe the use of Digital Spatial Profiling (DSP) technology to investigate SARS-CoV-2 infection and drive diagnostic, prevention, and treatment strategies.
The GeoMx DSP was used to profile lung tissue collected on autopsy from patients who had succumbed to COVID-19 infection. Researchers used the Cancer Transcriptome Atlas (CTA) plus a spike-in panel to detect additional lung genes and SARS-CoV-2 virus. In total, over 1,800 genes were interrogated as part of the study. This information enabled the researchers to connect bulk RNA sequencing data to the lung tissue's spatial architecture by looking at the distribution and transcriptional activity of cells, providing an important basis for understanding COVID-19 and lung pathology.
The first study, published in Nature Communications and led by Dr. Christopher Mason at Weill Cornell Medicine, was entitled "Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveal unique host responses, viral diversification, and drug interactions." In this study, the GeoMx platform was used to molecularly characterize alveolar lung tissue. The team found spatially-restricted expression of the gene ACE2—which is a SARS-CoV-2 cellular target—and SARS-CoV-2 virus in some of the same regions. From the spatially-resolved expression profiles, they were able to infer the abundance of different immune and non-immune cells and found unique cellular distributions in COVID-19 patients compared to normal control lung samples.
"We were interested in characterizing the diversity of SARS-CoV-2 circulating in the population as well as the diversity of response to infection within a single patient. By using cell-type deconvolution, we were able to measure relative levels of 16 different cell populations from COVID-19 cases and controls using a single slide from each patient," said Dr. Mason, who serves on NanoString's Scientific Advisory Board and is a paid consultant for the company. "This deep molecular profiling helped us create a more complete picture of how the virus circulates in the body and how it elicits a variable response in infected individuals."
More on Washingtoner
The second study, "The spatial landscape of lung pathology during COVID-19 progression", was published in Nature and was led by Dr. Robert Schwartz, Dr. Alain Borczuk, and Dr. Olivier Elemento at Weill Cornell Medicine. The team found a difference in immune composition between individuals with early (<14 days) versus late (>30 days) mortality after admission to a hospital with COVID-19 symptoms. In "early" patients, immune cells known as neutrophils were seen at rates comparable to other acute respiratory distress syndromes (ARDS). However, with time it appears that a different pattern emerges; namely, increased abundance of macrophages, more inflammation, and wound healing (fibrosis) in patients with late mortality.
"Spatial profiling of the samples allowed us to separately characterize the transcriptional response in the airway, alveolar, and vascular compartments of the lung, and enabled us to see that the early period of severe COVID-19 disease is comprised of inflammatory responses to SARS-CoV-2," said Dr. Schwartz. "We also discovered late COVID-19 might be driven by pathogen-independent mechanisms of an immune response with aberrant resolution."
"These studies demonstrate the value of the GeoMx Digital Spatial Profiler in characterizing the tissue damage induced by SARS-CoV-2 infection," said Sarah Warren, Ph.D., Senior Director of Translational Science at NanoString. "By applying high-plex molecular profiling on the formalin fixed, paraffin embedded (FFPE) tissues that are safe to work with from COVID-19 autopsies, we can understand how the virus is inducing and altering immune response and tissue repair in the patients' lungs."
The GeoMx Digital Spatial Profiler enables researchers to rapidly and quantitatively characterize tissue morphology with a high-throughput, high-plex RNA and protein profiling system that preserves precious samples for future analyses. NanoString and its collaborators have presented DSP data in dozens of abstracts at major scientific meetings, and in more than 40 peer reviewed publications, demonstrating DSP's utility to address a wide range of biological questions in FFPE and frozen tissues. Interested parties can learn more about DSP by visiting https://www.nanostring.com/scientific-content/technology-overview/digital-spatial-profiling-technology.
More on Washingtoner
NanoString launched its Technology Access Program (TAP) for the recently announced single and subcellular Spatial Molecular Imager to complement the existing TAP program for GeoMx. Under the program, customers can submit tissue samples to NanoString to be analyzed using both spatial profiling platforms and receive a complete data package. Researchers interested in participating in NanoString's Technology Access Program should contact the company at TAP@nanostring.com.
About NanoString Technologies, Inc.
NanoString Technologies is a leading provider of life science tools for discovery and translational research. The company's nCounter® Analysis System is used in life sciences research and has been cited in more than 4,000 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company's GeoMx® Digital Spatial Profiler enables highly-multiplexed spatial profiling of RNA and protein targets in a variety of sample types, including FFPE tissue sections.
For more information, please visit www.nanostring.com.
NanoString, NanoString Technologies, the NanoString logo, GeoMx, and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc. in various jurisdictions.
The GeoMx DSP was used to profile lung tissue collected on autopsy from patients who had succumbed to COVID-19 infection. Researchers used the Cancer Transcriptome Atlas (CTA) plus a spike-in panel to detect additional lung genes and SARS-CoV-2 virus. In total, over 1,800 genes were interrogated as part of the study. This information enabled the researchers to connect bulk RNA sequencing data to the lung tissue's spatial architecture by looking at the distribution and transcriptional activity of cells, providing an important basis for understanding COVID-19 and lung pathology.
The first study, published in Nature Communications and led by Dr. Christopher Mason at Weill Cornell Medicine, was entitled "Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveal unique host responses, viral diversification, and drug interactions." In this study, the GeoMx platform was used to molecularly characterize alveolar lung tissue. The team found spatially-restricted expression of the gene ACE2—which is a SARS-CoV-2 cellular target—and SARS-CoV-2 virus in some of the same regions. From the spatially-resolved expression profiles, they were able to infer the abundance of different immune and non-immune cells and found unique cellular distributions in COVID-19 patients compared to normal control lung samples.
"We were interested in characterizing the diversity of SARS-CoV-2 circulating in the population as well as the diversity of response to infection within a single patient. By using cell-type deconvolution, we were able to measure relative levels of 16 different cell populations from COVID-19 cases and controls using a single slide from each patient," said Dr. Mason, who serves on NanoString's Scientific Advisory Board and is a paid consultant for the company. "This deep molecular profiling helped us create a more complete picture of how the virus circulates in the body and how it elicits a variable response in infected individuals."
More on Washingtoner
- Stratum Nutrition's OVOLUX™ Named 2025 "Collagen Ingredient of the Year" by Beauty Innovation Awards
- Sons of Liberty Museum Unveils "America at 250" Mobile Exhibit on Veterans Day 2025
- Revenue Expansion, Regulatory Momentum, and a Leadership Position in the $750 Million Suicidal Depression: NRx Pharmaceuticals (N A S D A Q: NRXP)
- North 5th Street – Between North Tacoma Avenue and North Division Avenue – to Close in Phases for Maintenance Starting December 1
- Bent Danholm Releases New Video Breaking Down the Rising Debate Over 50-Year Mortgages
The second study, "The spatial landscape of lung pathology during COVID-19 progression", was published in Nature and was led by Dr. Robert Schwartz, Dr. Alain Borczuk, and Dr. Olivier Elemento at Weill Cornell Medicine. The team found a difference in immune composition between individuals with early (<14 days) versus late (>30 days) mortality after admission to a hospital with COVID-19 symptoms. In "early" patients, immune cells known as neutrophils were seen at rates comparable to other acute respiratory distress syndromes (ARDS). However, with time it appears that a different pattern emerges; namely, increased abundance of macrophages, more inflammation, and wound healing (fibrosis) in patients with late mortality.
"Spatial profiling of the samples allowed us to separately characterize the transcriptional response in the airway, alveolar, and vascular compartments of the lung, and enabled us to see that the early period of severe COVID-19 disease is comprised of inflammatory responses to SARS-CoV-2," said Dr. Schwartz. "We also discovered late COVID-19 might be driven by pathogen-independent mechanisms of an immune response with aberrant resolution."
"These studies demonstrate the value of the GeoMx Digital Spatial Profiler in characterizing the tissue damage induced by SARS-CoV-2 infection," said Sarah Warren, Ph.D., Senior Director of Translational Science at NanoString. "By applying high-plex molecular profiling on the formalin fixed, paraffin embedded (FFPE) tissues that are safe to work with from COVID-19 autopsies, we can understand how the virus is inducing and altering immune response and tissue repair in the patients' lungs."
The GeoMx Digital Spatial Profiler enables researchers to rapidly and quantitatively characterize tissue morphology with a high-throughput, high-plex RNA and protein profiling system that preserves precious samples for future analyses. NanoString and its collaborators have presented DSP data in dozens of abstracts at major scientific meetings, and in more than 40 peer reviewed publications, demonstrating DSP's utility to address a wide range of biological questions in FFPE and frozen tissues. Interested parties can learn more about DSP by visiting https://www.nanostring.com/scientific-content/technology-overview/digital-spatial-profiling-technology.
More on Washingtoner
- New Smile Now Introduces RAYFace 3D Scanner to Advance Digital Surgery
- Ali Alijanian, DDS Featured in The Profitable Dentist Magazine
- "Meet the Eatmons" Offer Financial Advice ahead of the Holidays
- CCHR: Study Finds Involuntary Commitment Fails to Prevent Suicide, Raises Risk
- Slotozilla's Q3 2025: SBC Lisbon Outcomes and Partnership Expansion
NanoString launched its Technology Access Program (TAP) for the recently announced single and subcellular Spatial Molecular Imager to complement the existing TAP program for GeoMx. Under the program, customers can submit tissue samples to NanoString to be analyzed using both spatial profiling platforms and receive a complete data package. Researchers interested in participating in NanoString's Technology Access Program should contact the company at TAP@nanostring.com.
About NanoString Technologies, Inc.
NanoString Technologies is a leading provider of life science tools for discovery and translational research. The company's nCounter® Analysis System is used in life sciences research and has been cited in more than 4,000 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company's GeoMx® Digital Spatial Profiler enables highly-multiplexed spatial profiling of RNA and protein targets in a variety of sample types, including FFPE tissue sections.
For more information, please visit www.nanostring.com.
NanoString, NanoString Technologies, the NanoString logo, GeoMx, and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc. in various jurisdictions.
Filed Under: Business
0 Comments
Latest on Washingtoner
- 2026 Oscars Betting Odds: One Battle After Another Favored for Best Picture
- Allen Field Co., Inc. Components Selected for Esko ArtiosCAD 3D Component Library
- Monroe Welcomes The Great Junk Hunt – This Vintage Market is Getting Ready for the Holidays!
- Thirteen Reasons Why Gyminny Kids Is San Diego's Best Gymnastics Gym
- Kennedy Funding Closes Challenging $3 Million Cash-Out Refinance Loan in Rural Washington State
- Heritage At Manalapan - A New Luxury Single Family Home Community Coming Late 2025
- The Lashe® Announces Exclusive November Savings for Lash and Beauty Professionals
- Corcoran DeRonja Real Estate Welcomes Siobhán Simões to Its Growing Team
- November is Lung Cancer Awareness Month: Screening Saves Aims to Increase Access to Lung Screenings in NC
- Valeo Health Leads a New Era of Longevity and Preventive Health in the UAE
- Torch Entertainment Presents The Frozen Zoo
- Spokane: Suspect Identified in Unsolved Murder of Margaret Anselmo
- ATTENTION: Investors, Suppliers, Travelers, & All Stakeholders In American Aviation
- Sweet Memories Vintage Tees Debuts Historic ORCA™ Beverage Nostalgic Soda Collection
- UK Financial Ltd Celebrates Global Recognition as MayaCat (MCAT) Evolves Into SMCAT — The World's First Meme Coin Under ERC-3643 Compliance
- U.S. Military to Benefit from Drone Tech Agreement with NovaSpark Energy, Plus Longer NASA Space Missions via Solar Power Leader: Ascent Solar $ASTI
- $76 Million in Gold & Silver Holdings and Expanding Production — Pioneering the Future of Gold: Asia Broadband Inc. (Stock Symbol: AABB) is Surging
- Wohler announces three SRT monitoring enhancements for its iVAM2-MPEG monitor and the addition of front panel PID selection of A/V/subtitle streams
- Schemawriter.ai launches WordPress plugin as industry leaders confirm - schema markup is critical
- 20 Million Financing to Accelerate Growth and Advance Digital Asset Strategy Secured for Super League (N A S D A Q: SLE)